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Abstract #1913

Incorporation of Nonzero Echo Times in the SPGR and bSSFP Signal Models used in mcDESPOT

Mustapha Bouhrara1 and Richard G. Spencer1

1NIA, NIH, Baltimore, MD, United States

Formulations of the two-component spoiled gradient recalled echo (SPGR) and balanced steady-state free precession (bSSFP) models that incorporate nonzero echo time (TE) effects are presented in the context of mcDESPOT and compared with the conventionally used SPGR and bSSFP models which ignore nonzero TEs. Relative errors in derived parameter estimates from conventional mcDESPOT, omitting TE effects, are assessed using simulations over a wide range of experimental and sample parameters. The neglect of nonzero TE leads to an overestimate of the SPGR and an underestimate of the bSSFP signals. These effects introduce large errors in parameter estimates derived from conventional mcDESPOT.

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