Abstract #1912

Quantitative image analysis based on Image registration of brain MR and SPECT for dopamine transporter imaging

Takeshi Hara¹, Yuta Takeda¹, Tetsuro Katafuchi², Taiki Nozaki³, Masaki Matsusako³, and Hiroshi Fujita¹

¹Intelligent Image Information, Gifu University Graduate School of Medicine, Gifu, Japan, ²Health Science, Gifu University of Medical Science, Seki, Japan, ³Radiology, St. Luke's International Hospital, Tokyo, Japan

Features in Parkinson's disease (PD) are a degeneration and loss of the dopamine neurons in striatum. 123I-FP-CIT can visualize the distribution by binding to the dopamine neurons. The radioactivated medicine is used for diagnosis of PD and Dementia with Lewy Bodies (DLB). The material can visualize activities in corpus striatum on SPECT images, but the location of the corpus striatum on SPECT images are often lost because of the low uptake. To realize a quantitative image analysis for the SPECT images, image registration technique to determine the region of corpus striatum on SPECT images are required to measure precise uptakes. In this study, we proposed an image fusion technique for SPECT and MR images by intervening CT image taken by SPECT/CT. We employed 30 cases of SPECT/CT and MR cases for the evaluation. 25 of 30 cases were registered correctly with registration errors less than 5mm. These results enable to measure precise uptake on SPECT images based on the segmentation results on MR images.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.