Abstract #1980

Diffusion MRI of neuro-plasticity following complex motor learning

Maya Faraggi¹, William D Richardson², Derek K Jones³, and Yaniv Assaf^4,5

¹Neurobiology, Tel Aviv University, Tel Aviv, Israel, ²Wolfson Institute for Biomedical Research, University College London, London, United Kingdom, ³CUBRIC, Cardiff University, Cardiff, United Kingdom, ⁴Tel Aviv University, Tel Aviv, Israel, ⁵EMRIC, Cardiff University, Cardiff, United Kingdom

Neuroplasticity is the capacity of the nervous system to modify its organization as a result of a dynamic internal or external environment. In this study we aim to use DTI to characterize plasticity dynamics in the mouse brain as a result of a task with two degrees of difficulty. In order to achieve that goal, we assessed motor learning ability using a running wheel with irregularly spaced rungs ("complex wheel"). Diffusion MRI revealed significant micro-structural changes in multiple brain areas expected to be affected by this task including the motor domain, sensory perception regions and white matter tracts .

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