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Abstract #1980

Diffusion MRI of neuro-plasticity following complex motor learning

Maya Faraggi1, William D Richardson2, Derek K Jones3, and Yaniv Assaf4,5

1Neurobiology, Tel Aviv University, Tel Aviv, Israel, 2Wolfson Institute for Biomedical Research, University College London, London, United Kingdom, 3CUBRIC, Cardiff University, Cardiff, United Kingdom, 4Tel Aviv University, Tel Aviv, Israel, 5EMRIC, Cardiff University, Cardiff, United Kingdom

Neuroplasticity is the capacity of the nervous system to modify its organization as a result of a dynamic internal or external environment. In this study we aim to use DTI to characterize plasticity dynamics in the mouse brain as a result of a task with two degrees of difficulty. In order to achieve that goal, we assessed motor learning ability using a running wheel with irregularly spaced rungs ("complex wheel"). Diffusion MRI revealed significant micro-structural changes in multiple brain areas expected to be affected by this task including the motor domain, sensory perception regions and white matter tracts .

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