Abstract #1981

Fractional diffusion as a probe of microstructural change in a mouse model of Duchenne Muscular Dystrophy

Matt G Hall¹, Paola Porcari², Andrew Blamire², and Chris A Clark¹

¹Institute of Child Health, University College London, London, United Kingdom, ²Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, United Kingdom

We apply a fractional diffusion model to preclinical data from a mouse model of Duchenne Muscular Dystrophy, and compare to histological measurements of the underlying tissue. We find that the alpha exponent of the model provides contrast which is indicative of the microstructural changes associated with DMD. We observe contrast between the wild type and mdx mouse model.

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