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Abstract #1984

Age-related changes of white matter diffusion anisotropy measures in old age observed with Double Diffusion Encoding

Marco Lawrenz1 and Juergen Finsterbusch1

1Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

With the help of double diffusion encoding experiments with two weighting periods applied successively microscopic tissue parameter can be gained. Rotationally invariant measures of the microscopic diffusion anisotropy such as the MA index may yield additional information complementary to DTI. Recent studies showed that MA can be determined in the living human brain, and normal values and their variation in groups of young and old healthy volunteers have been reported. In this study, the age-correlation of the diffusion anisotropy measures in terms of MA and FA values in a group of old volunteers (> 60 y) is discussed.

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