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Abstract #1987

Hemodynamic-independent fluctuation MRI using self-correction in idiopathic normal pressure hydrocephalus

Naoki Ohno1, Tosiaki Miyati1, Marina Takatsuji2, Mitsuhito Mase3, Tomoshi Osawa3, and Yuta Shibamoto4

1Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 2Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan, 3Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan, 4Department of Radiology, Nagoya City University, Nagoya, Japan

Apparent diffusion coefficient (ADC) of the brain significantly changed during the cardiac cycle because of the water-molecule fluctuation. Moreover, this information assists in the diagnosis of idiopathic normal pressure hydrocephalus (iNPH). However, these changes (ΔADC) are affected by cerebral blood flow. Therefore, we corrected the effect of blood flow by using the diffusion data to evaluate hemodynamic-independent water fluctuation in iNPH. Corrected-ΔADC was significantly higher in iNPH group compared with control and atrophic ventricular dilatation groups. Hemodynamically independent analysis for water fluctuation MRI makes it possible to obtain more detailed information on biomechanical properties in iNPH.

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