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Abstract #1986

DW-MRI for evaluating lesions classified as responding and non-responding on RECIST criteria in patients with relapsed epithelial ovarian and primary peritoneal cancer re-challenged with platinum-based chemotherapy

Jennifer C Wakefield1,2, Jessica M Winfield1,2, Veronica Morgan2, Alison MacDonald2, Susana Banerjee1,2, Andrew N Priest3, Rebecca A Quest4, Susan Freeman3, Andrea G Rockall4, and Nandita M deSouza1,2

1Division of Radiotherapy and Imaging, Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, 2The Royal Marsden Hospital, Sutton, United Kingdom, 3Department of Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 4Imaging Department, Imperial College Healthcare NHS Trust, London, United Kingdom

The utility of Diffusion-weighted MRI (DW-MRI) in defining response by volume reduction or for determining the time-course of apparent diffusion coefficient (ADC) changes indicative of response has not been evaluated in patients with relapsed ovarian or peritoneal cancer. We evaluated post-treatment change in volume and ADC in lesions classified by RECIST criteria as responders and non-responders. We found responding lesions show greater change in volume and equivalent change in ADC to non-responding lesions after one cycle of chemotherapy. In non-responding lesions, the change in these parameters continued at the same rate post-first cycle of chemotherapy, indicating a delayed response.

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