Abstract #1996

Imaging Three Dimensional Temporal Diffusion Spectrum Dispersion Profiles in the Brain

Dan Wu¹, Frances J Northington², and Jiangyang Zhang^1,3

¹Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, ²Pediatrics, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, ³Radiology, New York University School of Medicine, New Yourk, NY, United States

The dispersion profile of the temporal diffusion spectrum has been linked to key properties of tissue microstructures, however, its directional variance has not been shown. In this study, we extended the conventional one-dimensional dispersion profile to three-dimensional profile, and characterized its directionality with a tensor representation. The temporal diffusion dispersion (TDD) tensor demonstrated unique contrasts that reflected distinct microstructural organization in the mouse brain, and the high anisotropy from TDD tensors correlated with anisotropic structural arrangements, e.g., in the crossing fiber regions. The TDD contrasts are also sensitive to disrupted microstructures in a neonatal mouse model of hypoxic-ischemic injury.

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