Abstract #1995

Modelling of diffusion in cultured epithelial cell spheroids

Sisi Liang¹, Madiha Yunus², Eleftheria Panagiotaki ³, Byung Kim⁴, Timothy Stait-Gardner⁵, Mikhail Zubkov⁵, Brian Hawkett⁴, William Price⁵, Carl Power⁶, and Roger Bourne²

¹College of Engineering and Science, Victoria University, Melbourne, Australia, ²Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, ³Center for Medical Image Computing, University College London, London, United Kingdom, ⁴Key Centre For Polymer Colloids, University of Sydney, Sydney, Australia, ⁵Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Sydney, Australia, ⁶Mark Wainright Analytical Centre, The university of New South Wales, Sydney, Australia

Cultured epithelial cell spheroids demonstrate many of the physiological properties of glandular epithelia and provide an ideal experimental model for investigation of the distinctive structural properties that may contribute to the reported low water mobility in prostate, breast, and gut epithelia. The structural connections are very similar to those in intact tissue and thus they provide a more realistic model of tissue than previously investigated models based on pelleted yeast or erythrocyte cells. We report an investigation of the correlation between known cell sizes in a spheroid culture and restriction radius estimated by a model of diffusion MRI signals.

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