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Abstract #1995

Modelling of diffusion in cultured epithelial cell spheroids

Sisi Liang1, Madiha Yunus2, Eleftheria Panagiotaki 3, Byung Kim4, Timothy Stait-Gardner5, Mikhail Zubkov5, Brian Hawkett4, William Price5, Carl Power6, and Roger Bourne2

1College of Engineering and Science, Victoria University, Melbourne, Australia, 2Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, 3Center for Medical Image Computing, University College London, London, United Kingdom, 4Key Centre For Polymer Colloids, University of Sydney, Sydney, Australia, 5Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Sydney, Australia, 6Mark Wainright Analytical Centre, The university of New South Wales, Sydney, Australia

Cultured epithelial cell spheroids demonstrate many of the physiological properties of glandular epithelia and provide an ideal experimental model for investigation of the distinctive structural properties that may contribute to the reported low water mobility in prostate, breast, and gut epithelia. The structural connections are very similar to those in intact tissue and thus they provide a more realistic model of tissue than previously investigated models based on pelleted yeast or erythrocyte cells. We report an investigation of the correlation between known cell sizes in a spheroid culture and restriction radius estimated by a model of diffusion MRI signals.

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