Abstract #1998

The influence of T2 relaxation in measuring the restricted volume fraction in diffusion MRI

Silvia De Santis¹, Yaniv Assaf², and Derek Jones¹

¹Cardiff University, CUBRIC, Cardiff, United Kingdom, ²Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel

With the increasing popularity of multi-shell diffusion techniques to measure axonal density and diameter, the investigation of the exact origin of the contrast has become a hot topic. Here, we investigate the impact of the echo time in measuring the axonal density and show that the two water compartments are characterised by a different relaxation time T2, making the measures of the volume strongly dependent on the echo time. This suggests caution when comparing data acquired with different setups and introduces a new way of measuring the differential T2 properties of intra- and extra-axonal water pools.

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