Abstract #1999

Diffusion MRI: Disentangling Micro- from Mesostructure and Bayesian Parameter Evaluation

Marco Reisert¹, Elias Kellner¹, Bibek Dhital¹, Jürgen Hennig¹, and Valerij G. Kiselev¹

¹Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Diffusion-sensitized MRI probes the cellular structure of the human brain, but the primary microstructural information gets lost in averaging over higher-level, mesoscopic tissue organization such as different orientations of neuronal fibers. While such averaging is inevitable due to the limited imaging resolution, we propose a method for disentangling the microscopic cell properties from the effects of mesoscopic structure. The proposed method finds detectable parameters of a given microstructural model and calculates them within seconds, which makes it suitable for a broad range of applications.

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