Abstract #2000

Intracellular volume fraction estimation in vivo in single and crossing fibre regions

Sjoerd B Vos^1,2, Andrew Melbourne¹, John S Duncan^2,3, and Sebastien Ourselin¹

¹Translational Imaging Group, University College London, London, United Kingdom, ²MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, ³Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom

Intracellular volume fraction (ICVF) is a valuable biomarker of neurological disease. As one of two factors in g-ratio estimates it could potentially reveal axonal function from structural MRI measurements. Reliable ICVF estimation is critical for both purposes. With various diffusion models in existence for ICVF estimation, we compared the obtained ICVF values and their reproducibility in voxels with 1, 2, and 3 fibre populations between three diffusion modelling approaches. Absolute ICVF values vary significantly between models as well as between voxels with different fibre complexity.

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