Abstract #2001

Modeling diffusion of intracellular metabolites in the mouse brain up to very high b: diffusion in long fibers (almost) accounts for non-monoexponential attenuation

Marco Palombo^1,2, Clémence Ligneul^1,2, and Julien Valette^1,2

¹CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, ²CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

We investigate how metabolite diffusion measured up to very high b (60 ms/µm²) at relatively short diffusion time (63.2 ms) in the mouse brain can be explained in terms of simple geometries. We model cell fibers as isotropically oriented cylinders of infinite length, and show this can account very well for measured non-monoexponential attenuation. The only exception is NAA, for which the model extracts fiber diameter equal to 0. We show that is theoretically and experimentally compatible with a small fraction of the NAA pool being confined in highly restricted compartments (with short T₂), e.g. a mitochondrial pool.

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