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Abstract #2006

Does Myelin Water Influence DWI?

Kevin D Harkins1 and Mark D Does1,2,3,4

1Institute of Image Science, Vanderbilt University, Nashville, TN, United States, 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4Electrical Engineering, Vanderbilt University, Nashville, TN, United States

The presence and movement of myelin water is often neglected from models of DWI signal. This study presents a Monte Carlo simulation illustrating that myelin water diffusion can have a subtle but important impact on measured Dapp and Kapp values, and that incorporating myelin water diffusion can influence myelin-content dependent changes in Dapp and Kapp.

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