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Abstract #2007

Characterizing microstructural changes in Multiple Sclerosis lesions using advanced diffusion MRI at 3T and 7T

Silvia De Santis1,2, Matteo Bastiani2, Henk Jansma2, Amgad Droby3, Pierre Kolber3, Eberhard Pracht4, Tony Stoecker4, Frauke Zipp3, and Alard Roebroeck2

1Cardiff University, CUBRIC, Cardiff, United Kingdom, 2Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Neurology and Neuromaging Center, University Medical Center of the Johannes Gutenberg University, Mainz, Germany, 4German Center for Neurodegenerative diseases, Bonn, Germany

Aim of this work was to test the ability of conventional (i.e., DTI) and advanced (i.e., CHARMED, stretched exponential) diffusion methods to differentiate between Multiple Sclerosis lesions, normal appearing white matter and healthy controls, at both 3T and 7T. Advanced dMRI at 7T gives the best discriminating power between MS lesions and healthy tissue across WM; DTI is appropriate in areas of low fiber dispersion like the corpus callosum.

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