Abstract #2007

Characterizing microstructural changes in Multiple Sclerosis lesions using advanced diffusion MRI at 3T and 7T

Silvia De Santis^1,2, Matteo Bastiani², Henk Jansma², Amgad Droby³, Pierre Kolber³, Eberhard Pracht⁴, Tony Stoecker⁴, Frauke Zipp³, and Alard Roebroeck²

¹Cardiff University, CUBRIC, Cardiff, United Kingdom, ²Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Neurology and Neuromaging Center, University Medical Center of the Johannes Gutenberg University, Mainz, Germany, ⁴German Center for Neurodegenerative diseases, Bonn, Germany

Aim of this work was to test the ability of conventional (i.e., DTI) and advanced (i.e., CHARMED, stretched exponential) diffusion methods to differentiate between Multiple Sclerosis lesions, normal appearing white matter and healthy controls, at both 3T and 7T. Advanced dMRI at 7T gives the best discriminating power between MS lesions and healthy tissue across WM; DTI is appropriate in areas of low fiber dispersion like the corpus callosum.

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