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Abstract #2015

Extensive White Matter Damage in Neuromyelitis Optica Assessed by Neurite Orientation Dispersion and Density Imaging: A Tact-Based Spatial Statistics study

Tomohiro Takamura1, Shou Murata2, Koji Kamagata3, Kouhei Tsuruta2, Masaaki Hori3, Michimasa Suzuki3, and Shigeki Aoki3

1University of Yamanashi, Yamanashi, Japan, 2Tokyo Metropolitan University, Tokyo, Japan, 3Juntendo University, Tokyo, Japan

Recently, patients with neuromyelitis optica (NMO) have shown extensive white matter damage, which could be related not only to Wallerian degeneration resulting from lesions of spinal cord or optic tracts but also to demyelination by using diffusion-tensor (DT) MRI imaging. This study aimed to evaluate the expansion of white matter damage in NMO assessed using neurite orientation dispersion and density imaging (NODDI), as well as its relationship with disease severity by applying Tact Based Spatial Statistics (TBSS).

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