Abstract #2015

Extensive White Matter Damage in Neuromyelitis Optica Assessed by Neurite Orientation Dispersion and Density Imaging: A Tact-Based Spatial Statistics study

Tomohiro Takamura¹, Shou Murata², Koji Kamagata³, Kouhei Tsuruta², Masaaki Hori³, Michimasa Suzuki³, and Shigeki Aoki³

¹University of Yamanashi, Yamanashi, Japan, ²Tokyo Metropolitan University, Tokyo, Japan, ³Juntendo University, Tokyo, Japan

Recently, patients with neuromyelitis optica (NMO) have shown extensive white matter damage, which could be related not only to Wallerian degeneration resulting from lesions of spinal cord or optic tracts but also to demyelination by using diffusion-tensor (DT) MRI imaging. This study aimed to evaluate the expansion of white matter damage in NMO assessed using neurite orientation dispersion and density imaging (NODDI), as well as its relationship with disease severity by applying Tact Based Spatial Statistics (TBSS).

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