Abstract #2014

Statistical assessment of a model combining IVIM and T2 decay for multi-b-value, multi-echo-time DW-MRI in abdominal organs

Matthew R Orton¹, Neil P Jerome¹, Thorsten Feiweier², Dow-Mu Koh³, Martin O Leach⁴, and David J Collins⁴

¹Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, ²Siemens Healthcare, Erlangen, Germany, ³Department of Radiology, Royal Marsden NHS Foundation Trust, London, United Kingdom, ⁴CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom

The IVIM model is essentially a two-compartment model, and it has previously been noted that the T2 relaxation times in each compartment may not be equal. This work uses the Akaike Information Criterion to compare two combined IVIM-T2 models using data acquired in various abdominal organs with all combinations of five echo-times and six b-values. The first model has the same T2 in each compartment, the second has different T2s, and we show that the second model has greater statistical support in the liver (but not spleen or kidney), implying that both T2 values can be measured in this organ.

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