Abstract #2013

White matter alterations in young adults born extremely preterm: a microstructural point of view.

Zach Eaton-Rosen¹, Andrew Melbourne¹, Joanne Beckmann², Eliza Orasanu¹, Nicola Stevens³, David Atkinson⁴, Neil Marlow², and Sebastien Ourselin¹

¹TIG, UCL, London, United Kingdom, ²UCL EGA Institute for Women's Health, London, United Kingdom, ³UCLH, London, United Kingdom, ⁴CMIC, UCL, London, United Kingdom

We used NODDI and DTI in order to investigate the differences in white matter between young adults born at term, and those born at fewer than 26 weeks completed gestation, using TBSS. The differences in FA were closely mirrored by the differences in orientation dispersion index (ODI) while the intra-axonal volume fraction (Vi) did not show significant differences in the same regions. This suggests that the ODI may be more sensitive to indicators of being born preterm than Vi in the white matter.

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