NODDI and AxCaliber diffusion-weighted imaging at ultrahigh field for microstructural imaging of the mouse spinal cord
Ahmad Joman Alghamdi1,2, Hari K Ramachandran3, Ian M Brereton1, and Nyoman D Kurniawan1
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2College of Health Sciences, Taif University, Taif, Saudi Arabia, 3Computer Science and Engineering, SRM University, Kattankulathur, India
DTI has been used to measure changes in spinal
cord WM, but lacks the specificity in measuring changes in GM and axonal
diameter. This study aims to apply NODDI and AxCaliber techniques to measure
characteristics of the lumbar spine in C57BL/6 mice, in-vivo at 9.4T and ex-vivo
at 16.4T. The GM orientation distribution index is 3 times that of the WM, and the
correlation of ODI to FA is r=–0.9, P<<0.01 for GM and r=–0.56, P<<0.01
for WM. AxCaliber analysis determined WM axon diameter populations with an average
of 1.55±0.15mm (in-vivo);
and 1.37±0.20 mm (ex-vivo).
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