Abstract #2012

NODDI and AxCaliber diffusion-weighted imaging at ultrahigh field for microstructural imaging of the mouse spinal cord

Ahmad Joman Alghamdi^1,2, Hari K Ramachandran³, Ian M Brereton¹, and Nyoman D Kurniawan¹

¹Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ²College of Health Sciences, Taif University, Taif, Saudi Arabia, ³Computer Science and Engineering, SRM University, Kattankulathur, India

DTI has been used to measure changes in spinal cord WM, but lacks the specificity in measuring changes in GM and axonal diameter. This study aims to apply NODDI and AxCaliber techniques to measure characteristics of the lumbar spine in C57BL/6 mice, in-vivo at 9.4T and ex-vivo at 16.4T. The GM orientation distribution index is 3 times that of the WM, and the correlation of ODI to FA is r=–0.9, P<<0.01 for GM and r=–0.56, P<<0.01 for WM. AxCaliber analysis determined WM axon diameter populations with an average of 1.55±0.15mm (in-vivo); and 1.37±0.20 mm (ex-vivo).

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