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Abstract #2011

Acquisition Protocol Optimization for Axon Diameter Mapping at High-Performance Gradient Systems – A Simulation Study

Jonathan I Sperl1, Ek Tsoon Tan2, Miguel Molina Romero1,3, Marion I Menzel1, Chris J Hardy2, Luca Marinelli2, and Thomas K.F. Foo2

1GE Global Research, GARCHING, Germany, 2GE Global Research, NISKAYUNA, NY, United States, 3Institute of Medical Engineering, Technische Universität München, GARCHING, Germany

The measurement of axonal diameter by diffusion MRI techniques has assumed major interest in the research community. While most work has focused on developing and comparing various multi-compartment models, only minor efforts have been undertaken to optimize corresponding acquisition protocols. In this work we perform simulations using a rather simple two-compartment model, but study the effect of various choices of acquisition parameters on the precision and the bias of the fitted parameters. More precisely, we analyze potential sampling strategies in the 2D design space spanned by the two timing parameters (Δ, δ) of the diffusion encoding.

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