Abstract #2020

Detection of lymphocytes fractions using temporal diffusion spectroscopy

Johannes Riegler¹, Maj Hedehus¹, and Richard A. D. Carano¹

¹Biomedical Imaging, Genentech, South San Francisco, CA, United States

Inflammation and T-cell infiltration are important prognostic biomarkers for cancer immunotherapies.¹ Current clinical practice relies on histological assessment of tissue biopsies which is invasive and prone to sampling errors. Temporal diffusion spectroscopy, particularly with short effective diffusion times can estimate cell sizes.^2,3 Lymphocytes have small diameters compared to typical tumor cells. We therefore tested the ability of temporal diffusion spectroscopy to differentiate between pellets of tumor cells mixed with a varying amount of activated lymphocytes. We observed clearly separable diffusion characteristics for samples containing > 20% lymphocytes indicating that this approach may have potential to quantify inflammation in highly inflamed tissues.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.