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Abstract #2020

Detection of lymphocytes fractions using temporal diffusion spectroscopy

Johannes Riegler1, Maj Hedehus1, and Richard A. D. Carano1

1Biomedical Imaging, Genentech, South San Francisco, CA, United States

Inflammation and T-cell infiltration are important prognostic biomarkers for cancer immunotherapies.1 Current clinical practice relies on histological assessment of tissue biopsies which is invasive and prone to sampling errors. Temporal diffusion spectroscopy, particularly with short effective diffusion times can estimate cell sizes.2,3 Lymphocytes have small diameters compared to typical tumor cells. We therefore tested the ability of temporal diffusion spectroscopy to differentiate between pellets of tumor cells mixed with a varying amount of activated lymphocytes. We observed clearly separable diffusion characteristics for samples containing > 20% lymphocytes indicating that this approach may have potential to quantify inflammation in highly inflamed tissues.

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