Abstract #2021

Estimation of Fiber Packing Correlation Length by Varying Diffusion Gradient Pulse Duration

Hong-Hsi Lee¹, Gregory Lemberskiy¹, Els Fieremans¹, and Dmitry S. Novikov¹

¹New York University, Center for Biomedical Imaging, New York, NY, United States

Finite pulse duration $$$\delta$$$ of diffusion gradient has typically been a source of bias for quantifying microstructure. Here, we suggest to use the diffusivity dependence on $$$\delta$$$ to reveal the correlation length of the fiber packing, an essential μm–level characteristic of microstructure, thereby turning the finite pulse duration to our advantage. We validate our method in a fiber phantom that mimics an axonal packing geometry, and the estimated correlation length matches the fiber radius. Future work will focus on the evaluation of its potential as biomarkers for in vivo brain scans, such as axonal density and outer axonal diameters.

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