Abstract #2022

Detection of Early Emphysema by Quantifying Lung Terminal Airways with Hyperpolarized 129Xe Diffusion MRI

Weiwei Ruan¹, Jianping Zhong¹, Ke Wang², Yeqing Han¹, and Xin Zhou¹

¹Wuhan Institute of Physical and Mathematics,Chinese Academy of Sciences, Wuhan, China, People's Republic of, ²Department of MRI, zhongnan hospital of wuhan university, Wuhan, China, People's Republic of

To detect the early emphysema, hyperpolarized xenon diffusion MRI with multi-b values was used to quantify the lung terminal airways in five initial stages of emphysematous rats and five control rats. The D_L (longitudinal diffusion coefficient), r, h, L_M and S/V in the emphysematous group showed significant differences compared to those in the control group (P<0.05) and also exhibited a strong linear correlation (|r|>0.8) to Lm from histology for all the rats. The results showed multi-b diffusion MRI of hyperpolarized xenon has potential for the diagnosis of emphysema at the early stage.

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