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Abstract #2022

Detection of Early Emphysema by Quantifying Lung Terminal Airways with Hyperpolarized 129Xe Diffusion MRI

Weiwei Ruan1, Jianping Zhong1, Ke Wang2, Yeqing Han1, and Xin Zhou1

1Wuhan Institute of Physical and Mathematics,Chinese Academy of Sciences, Wuhan, China, People's Republic of, 2Department of MRI, zhongnan hospital of wuhan university, Wuhan, China, People's Republic of

To detect the early emphysema, hyperpolarized xenon diffusion MRI with multi-b values was used to quantify the lung terminal airways in five initial stages of emphysematous rats and five control rats. The DL (longitudinal diffusion coefficient), r, h, LM and S/V in the emphysematous group showed significant differences compared to those in the control group (P<0.05) and also exhibited a strong linear correlation (|r|>0.8) to Lm from histology for all the rats. The results showed multi-b diffusion MRI of hyperpolarized xenon has potential for the diagnosis of emphysema at the early stage.

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