Abstract #2023

A Time-Efficient Acquisition Protocol For Multi-Purpose Diffusion‑Weighted Microstructural Imaging At 7T

Farshid Sepehrband^1,2, Kieran O’Brien^1,3, and Markus Barth¹

¹Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ²Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, CA, United States, ³Siemens Healthcare Pty Ltd, Brisbane, Australia

Several diffusion-weighted MRI techniques for modeling tissue microstructure have been developed and validated during the past two decades. While offering various neuroanatomical inferences, these techniques differ in their proposed optimal acquisition design, which impede clinicians and researchers to benefit from all potential inference methods, particularly when limited time is available. We examined the performance of the most common diffusion models with respect to acquisition parameters at 7T when limiting the acquisition time to about 10 minutes. The most balanced compromise among all combinations in terms of the robustness of the estimates was a two-shell scheme with b-values of 1,000 and 2,500 s/mm² with 75 diffusion-encoding gradients, 25 and 50 samples for low and high b-values, respectively.

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