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Abstract #2025

Single Compartment model estimates of acinar duct measurements from inhaled noble gas MRI: Proof of Concept in alpha-1 antitrypsin deficiency emphysema

Eric Lessard1, Alexei Ouriadov1, David G McCormack2, and Grace Parraga1

1Robarts Research Institute, The University of Western Ontario, London, ON, Canada, 2Department of Medicine, The University of Western Ontario, London, ON, Canada

Diffusion-weighted MRI provides a way to non-invasively estimate in vivo morphometry measurements of the alveolar ducts. Current modelling approaches may not be appropriate for cases of severe tissue destruction where the geometry of the acinar ducts may not be uniform, nor cylindrical. Therefore, in this proof-of-concept evaluation, we used a single-compartment model and multiple b-value diffusion-weighted noble gas pulmonary MRI to generate estimates of acinar duct surface-to-volume ratio and mean-linear-intercept. In cases of very severe emphysema that accompany alpha-one antitrypsin deficiency, this approach well-approximated the severity of lung disease, while the cylindrical model did not.

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