Abstract #2028

Correlation of diffusion-weighted MRI with cellularity in glandular breast tissue

Narina Norddin^1,2, Nyoman Kurniawan³, Gary Cowin³, Carl Power⁴, Geoffrey Watson⁵, Esther Myint⁶, Laurence Gluch⁷, and Roger Bourne¹

¹University of Sydney, Sydney, Australia, ²International Islamic University Malaysia, Pahang, Malaysia, ³University of Queensland, Brisbane, Australia, ⁴University of New South Wales, Sydney, Australia, ⁵Royal Prince Alfred Hospital, Sydney, Australia, ⁶Douglass Hanly Moir Pathology, Sydney, Australia, ⁷The Strathfield Breast Centre, Sydney, Australia

Although diffusivity (ADC) changes in tissue are commonly attributed to variations in ‘cellularity’, direct evidence from breast tissue studies is limited and inconsistent. Here we report a diffusion microimaging and histology investigation of the correlation of mean diffusivity (MD) with cellularity in the glandular component of breast tissue. Diffusion microimaging was performed at 16.4T on fixed normal and cancer tissue samples and matched with post MRI histology. There was a moderate correlation between MD and nuclear count, but only a weak correlation between MD and nuclear area.

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