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Abstract #2028

Correlation of diffusion-weighted MRI with cellularity in glandular breast tissue

Narina Norddin1,2, Nyoman Kurniawan3, Gary Cowin3, Carl Power4, Geoffrey Watson5, Esther Myint6, Laurence Gluch7, and Roger Bourne1

1University of Sydney, Sydney, Australia, 2International Islamic University Malaysia, Pahang, Malaysia, 3University of Queensland, Brisbane, Australia, 4University of New South Wales, Sydney, Australia, 5Royal Prince Alfred Hospital, Sydney, Australia, 6Douglass Hanly Moir Pathology, Sydney, Australia, 7The Strathfield Breast Centre, Sydney, Australia

Although diffusivity (ADC) changes in tissue are commonly attributed to variations in ‘cellularity’, direct evidence from breast tissue studies is limited and inconsistent. Here we report a diffusion microimaging and histology investigation of the correlation of mean diffusivity (MD) with cellularity in the glandular component of breast tissue. Diffusion microimaging was performed at 16.4T on fixed normal and cancer tissue samples and matched with post MRI histology. There was a moderate correlation between MD and nuclear count, but only a weak correlation between MD and nuclear area.

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