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Abstract #2036

The best of both worlds: Combining the strengths of TBSS and tract-specific measurements for group-wise comparison of white matter microstructure

Greg D Parker1, Dafydd LLoyd2, and Derek K Jones1,3

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Ysgol Gyfun Gwyr, Swansea, United Kingdom, 3Neuroscience and Mental Health Research Institute (NMHRI), School of Medicine, Cardiff University, Cardiff, United Kingdom

Tract-specific microstructural measurements are key to many white matter studies. Common tract-specific measurement strategies average measurements along tracts of interest, but are insensitive to localised changes. Alternatively, by searching radially to a co-registered tract skeleton, tract based spatial statistics1 provides desirable localised comparisons. However, considering one value at each point (the highest value found by radial search), increases susceptibility to outliers, and misses the SNR benefit of averaging multiple estimates within a locale. We propose a hybrid method using tract skeletons to divide streamlines into localised sections, comparing averages within each section. Example results in remitted depression are presented.

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