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Abstract #2035

Optimization of acquisition parameters for diffusion MRI using chemical tracing

Giorgia Grisot1,2, Julia Lehman3, Suzanne N Haber3, and Anastasia Yendiki2

1Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, 3University of Rochester School of Medicine, Rochester, NY, United States

Determining the optimal diffusion MRI (dMRI) acquisition scheme for reconstructing a brain network of interest with tractography is an open problem, and the lack of ground truth on brain connections makes it challenging to resolve. We use chemical tracing and ex vivo dMRI in macaques to optimize dMRI acquisition with respect to tractography accuracy. We present preliminary results illustrating that 1. There is an upper bound to the angular resolution of dMRI, beyond which tractography accuracy does not improve, and 2. That this finding likely generalizes to in vivo human dMRI.

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