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Abstract #2040

Diffusion-weighted imaging with multiple diffusion time to assess water-exchange between restricted and hindered diffusion components in vivo

Yasuhiko Tachibana1,2, Takayuki Obata1,2, Hiroki Tsuchiya1, Tokuhiko Omatsu1,2, Riwa Kishimoto1,2, Thorsten Feiweier3, and Hiroshi Tsuji1

1Research Center of Charged Particle Therapy, National Institute of Radiological Science, Chiba, Japan, 2Applied MRI Research, National Institute of Radiological Science, Chiba, Japan, 3Siemens Healthcare GmbH, Erlangen, Germany

We performed multi-b and multi-diffusion-time DWI (MbMdt-DWI) on human brain to visualize the mixture of restricted and hindered diffusion components, and also the water exchange between them. The diffusion parameters including the exchange time were calculated. The observed signal patterns clearly indicated the existence of the inter-compartmental water exchange. The calculated exchange time was within the appropriate range assumed from a previous cell-based study in vitro. MbMdt-DWI may be useful for assessing micro-diffusion in human brain.

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