Abstract #2042

Assessment of Early Renal Fibrosis Induced in a Murine Model of Streptozotocin Induced Diabetes

Yet Yen Yan¹, Tiffany Hennedige¹, Tong San Koh¹, Lei Zhou², Septian Hartono³, Helmut Rumpel³, Laurent Martarello⁴, James Boon Kheng Khoo¹, Dow-Mu Koh⁵, Kai Hsiang Chuang⁶, Tony Kiat Hon Lim³, Yock Young Dan², and Choon Hua Thng¹

¹National Cancer Centre Singapore, Singapore, Singapore, ²National University Hospital, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore, ⁴Roche Translational Medicine Hub, Singapore, Singapore, ⁵Royal Marsden Hospital, London, United Kingdom, ⁶Singapore BioImaging Consortium, Singapore, Singapore

Streptozotocin induced diabetes was created in twenty mice while eighteen mice served as control. DTI & IVIM were performed at 0, 12 and 24 weeks after injection of streptozotocin. Histopathological analysis confirmed fibrosis in all diabetic mice. Increase in ADC & tissue diffusivity were found in the diabetes group at week 12, which might reflect an increased tubule volume that outweighed the effects of early fibrosis. FA was significantly reduced in the diabetes group at week 12 and represented tubular damage of renal fibrosis. This study showed the potential of FA as a biomarker of early diabetic nephropathy.

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