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Abstract #2042

Assessment of Early Renal Fibrosis Induced in a Murine Model of Streptozotocin Induced Diabetes

Yet Yen Yan1, Tiffany Hennedige1, Tong San Koh1, Lei Zhou2, Septian Hartono3, Helmut Rumpel3, Laurent Martarello4, James Boon Kheng Khoo1, Dow-Mu Koh5, Kai Hsiang Chuang6, Tony Kiat Hon Lim3, Yock Young Dan2, and Choon Hua Thng1

1National Cancer Centre Singapore, Singapore, Singapore, 2National University Hospital, Singapore, Singapore, 3Singapore General Hospital, Singapore, Singapore, 4Roche Translational Medicine Hub, Singapore, Singapore, 5Royal Marsden Hospital, London, United Kingdom, 6Singapore BioImaging Consortium, Singapore, Singapore

Streptozotocin induced diabetes was created in twenty mice while eighteen mice served as control. DTI & IVIM were performed at 0, 12 and 24 weeks after injection of streptozotocin. Histopathological analysis confirmed fibrosis in all diabetic mice. Increase in ADC & tissue diffusivity were found in the diabetes group at week 12, which might reflect an increased tubule volume that outweighed the effects of early fibrosis. FA was significantly reduced in the diabetes group at week 12 and represented tubular damage of renal fibrosis. This study showed the potential of FA as a biomarker of early diabetic nephropathy.

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