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Abstract #2043

Can Cramer-Ráo Lower Bound be used to find optimal b-values for IVIM?

Oscar Gustafsson1,2, Maria Ljungberg1,2, and Göran Starck1,2

1Department of Radiation Physics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

Cramer-Ráo Lower Bound is commonly used in experiment design optimization. Here we use it to find optimal b-value schemes for IVIM imaging. The optimization was generalized with regard to averaging and the characteristics of the results, given the input and the constraints, were studied. The resulting schemes never included more than the minimum number of four unique b-values, even though multiple sets of tissue parameters were included in the optimization. The optimized b-value schemes were compared to a typical one using simulations.

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