Abstract #2051

Rapid Estimation of IVIM Pseudo-Diffusion Fraction with Correction of TE Dependence

Neil Peter Jerome¹, Matthew R Orton¹, Thorsten Feiweier², Dow-Mu Koh³, Martin O Leach¹, and David J Collins¹

¹CRUK Cancer Imaging Centre, Division of Radiotherapy & Imaging, Institute of Cancer Research, London, United Kingdom, ²Siemens Healthcare GmbH, Erlangen, Germany, ³Department of Radiology, Royal Marsden Hospital, London, United Kingdom

The biexponential IVIM model of diffusion does not account for distinct T₂ values for the two components, commonly interpreted as blood and tissue, leading to a TE dependence of the pseudo-diffusion volume fraction parameter f. In this volunteer study, the addition of a small number of DWI scans at different TEs allows for fitting of an extended T2-IVIM model, returning TE-independent estimations of liver f (18.26±7.3 % compared to 27.88±6.0 % from conventional IVIM fitting), and T₂s of 77.6 ± 30.2 and 42.1 ± 6.8 ms for pseudo- and true diffusion compartments, respectively.

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