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Abstract #2051

Rapid Estimation of IVIM Pseudo-Diffusion Fraction with Correction of TE Dependence

Neil Peter Jerome1, Matthew R Orton1, Thorsten Feiweier2, Dow-Mu Koh3, Martin O Leach1, and David J Collins1

1CRUK Cancer Imaging Centre, Division of Radiotherapy & Imaging, Institute of Cancer Research, London, United Kingdom, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Department of Radiology, Royal Marsden Hospital, London, United Kingdom

The biexponential IVIM model of diffusion does not account for distinct T2 values for the two components, commonly interpreted as blood and tissue, leading to a TE dependence of the pseudo-diffusion volume fraction parameter f. In this volunteer study, the addition of a small number of DWI scans at different TEs allows for fitting of an extended T2-IVIM model, returning TE-independent estimations of liver f (18.26±7.3 % compared to 27.88±6.0 % from conventional IVIM fitting), and T2s of 77.6 ± 30.2 and 42.1 ± 6.8 ms for pseudo- and true diffusion compartments, respectively.

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