Abstract #2052

Validation of MD map calculation from DWI acquired on a 0.35T MRI scanner in Malawi for acute cerebral malaria

Yuchuan Zhuang¹, Samuel D. Kampondeni^2,3, Madalina Tivarus², Michael J. Potchen², Gretchen L. Birbeck⁴, and Jianhui Zhong²

¹Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ²Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, ³MRI Center, Queen Elizabeth Central Hospital, Blantyre, Malawi, ⁴Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States

Cerebral malaria (CM) is an often fatal disease that still devastates children in Africa. In Malawi, MRIs at 0.35T are obtained on pediatric CM patients, but quantitative analysis remains challenging. This report validates the 0.35T DWI measurements by comparing diffusion scans of normal adult subjects on both 0.35T and 3T MRI scanners. We used ROI analysis, regression analysis and histogram for quantitative validation. Strong consistency between the two data sets indicates that the DWI findings obtained on the 0.35T in Malawi can be used despite its inherent limitations.

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