Abstract #2064

LOCAL ANALYSIS OF TRACK DENSITY IMAGING FOR THE DETECTION OF WHITE MATTER ALTERATIONS

Rodrigo de Luis-Garcia¹, Angel Luis Guerrero², Miguel Angel Tola-Arribas³, and Santiago Aja-Fernandez¹

¹Universidad de Valladolid, Valladolid, Spain, ²Hospital Clinico Universitario, Valladolid, Spain, ³Hospital Universitario Rio Hortega, Valladolid, Spain

Track-Density Imaging (TDI) can provide super resolution images of the white matter of the brain. As it is based on the results of a whole brain tractography process, it comprises information from different features of the white matter diffusion. We exploit this information by proposing a local analysis approach for TDI, and test it on two different datasets where conventional TBSS analysis using FA did not yield any significant differences. Results revealed the proposed method to be extremely sensitive in the detection of white matter abnormalities, making it a promising tool for white matter group studies.

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