Abstract #2063

Effects of cortical regions of interests on tractography and brain connectivity quantification

Tina Jeon¹, Virendra Mishra², and Hao Huang^1,3

¹Radiology Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, ³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Dense white matter (WM) zones just beneath cerebral cortex impede tracking from a cortical region of interest with diffusion MRI data. To address this tracing problem, we can either dilate the parcellated cortex into the adjacent WM to initiate tracing or trace directly from WM interior to these dense WM zones. Here we evaluated with diffusion MRI data from three developmental age groups 1) how much dilation from the segmented cortical gyrus would be sufficient for appropriate WM tracing; and 2) if tracing directly from the WM immediately beneath the dense WM zones will yield the same tractography results.

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