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Abstract #2116

Iron-based T1 MRI contrast agent for MR-guided drug delivery from temperature sensitive liposomes

Esther Kneepkens1, Adriana Fernandes2, Klaas Nicolay3, and Holger GrĂ¼ll3,4

1Biomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Universidade de Lisboa, Lisbon, Portugal, 3Eindhoven University of Technology, Eindhoven, Netherlands, 4Philips Research, Eindhoven, Netherlands

The aim of this study was to investigate the potential of Fe(III) N-succinyl deferoxamine (Fe-SDFO) as a safe T1 contrast agent for encapsulation in temperature sensitive liposomes (TSLs) in order to visualize drug release from TSLs when using Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU). Two TSLs were developed that contained either Fe-SDFO or doxorubicin. Both TSLs showed suitable release and stability characteristics in vitro. An in vivo proof-of-concept study was carried out in tumor-bearing rats treated with MR-HIFU. Treated tumors showed an increase in R1 and future work aims to correlate the R1 change with tumor drug concentrations.

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