Abstract #2116

Iron-based T1 MRI contrast agent for MR-guided drug delivery from temperature sensitive liposomes

Esther Kneepkens¹, Adriana Fernandes², Klaas Nicolay³, and Holger Grüll^3,4

¹Biomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ²Universidade de Lisboa, Lisbon, Portugal, ³Eindhoven University of Technology, Eindhoven, Netherlands, ⁴Philips Research, Eindhoven, Netherlands

The aim of this study was to investigate the potential of Fe(III) N-succinyl deferoxamine (Fe-SDFO) as a safe T₁ contrast agent for encapsulation in temperature sensitive liposomes (TSLs) in order to visualize drug release from TSLs when using Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU). Two TSLs were developed that contained either Fe-SDFO or doxorubicin. Both TSLs showed suitable release and stability characteristics in vitro. An in vivo proof-of-concept study was carried out in tumor-bearing rats treated with MR-HIFU. Treated tumors showed an increase in R₁ and future work aims to correlate the R₁ change with tumor drug concentrations.

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