Abstract #2117

MR-guided focused ultrasound for antibody delivery in a brain metastasis model

Thiele Kobus^1,2, Yongzhi Zhang², Natalia Vykhodtseva², and Nathan McDannold²

¹Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Radiology, Brigham and Women's Hospital, Boston, MA, United States

We studied the treatment effect of HER2-targeting antibodies in combination with MR-guided focused ultrasound (FUS) to disrupt the blood-brain barrier in a breast cancer brain metastasis model. Tumors were implanted in rats and animals either received no treatment, six weekly treatments with antibodies, or six treatments of the antibodies combined with FUS-mediated BBB disruption. MR was used to guide the treatments and monitor tumor volume. 4/10 animals in the FUS+antibody-group responded to the treatment, but none of the other animals did. We could not explain with our results why only some of the FUS+antibody-animals responded and this requires further investigation.

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