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Abstract #2117

MR-guided focused ultrasound for antibody delivery in a brain metastasis model

Thiele Kobus1,2, Yongzhi Zhang2, Natalia Vykhodtseva2, and Nathan McDannold2

1Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 2Radiology, Brigham and Women's Hospital, Boston, MA, United States

We studied the treatment effect of HER2-targeting antibodies in combination with MR-guided focused ultrasound (FUS) to disrupt the blood-brain barrier in a breast cancer brain metastasis model. Tumors were implanted in rats and animals either received no treatment, six weekly treatments with antibodies, or six treatments of the antibodies combined with FUS-mediated BBB disruption. MR was used to guide the treatments and monitor tumor volume. 4/10 animals in the FUS+antibody-group responded to the treatment, but none of the other animals did. We could not explain with our results why only some of the FUS+antibody-animals responded and this requires further investigation.

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