Abstract #2119

MR-guided high intensity focused ultrasound mediated hyperthermia for targeted drug delivery to treat pancreatic cancer

Navid Farr¹, Yak-Nam Wang², Samantha D’Andrea³, Frank Starr², Ari Partanen⁴, Kayla Gravelle³, Donghoon Lee⁵, and Joo Ha Hwang^1,3

¹Department of Bioengineering, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Department of Medicine, University of Washington, Seattle, WA, United States, ⁴Philips Healthcare, Andover, MA, United States, ⁵Department of Radiology, University of Washington, Seattle, WA, United States

Pancreatic cancer has one of the lowest survival rates because current therapies are ineffective. Dense stromal tissue and poor vascular perfusion limits drug penetration and uptake into the tumor. Growing evidence suggests that hyperthermia in combination with temperature sensitive liposomal drug delivery can lead to increased organ perfusion and drug extravasation resulting in high local drug concentration. We performed MR-guided heating methods that enable accurate and precise spatial and temporal control of heating. Enhanced drug delivery was achieved to treat pancreatic tumors using Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) in conjunction with a heat triggered drug delivery system.

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