Abstract #2241

Multi-parametric assessment of thigh muscles in patients with limb girdle muscular dystrophies (LGMD): preliminary results.

Alberto De Luca^1,2, Maria Grazia D'Angelo³, Denis Peruzzo², Fabio Triulzi⁴, Alessandra Bertoldo¹, and Filippo Arrigoni²

¹Department of Information Engineering, University of Padova, Padova, Italy, ²Neuroimaging Lab, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, ³Functional Rehabilitation Unit, Neuromuscular Disorders, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, ⁴Department of Neuroradiology, Scientific Institute IRCCS Ca Granda Foundation - Ospedale Maggiore Policlinico, Milan, Italy

Limb girdle muscular dystrophies (LGMD) are a heterogeneous family of disorders characterized by the substitution of muscles with fat and fibrotic tissue. In this work we show the initial results of our acquisition protocol, that included DW-MRI, T₂ mapping and DIXON imaging, on two subtypes of LGMD (type 2A and 2B). Statistical tests and Pearson’s correlation were performed on parametric maps at single muscle level. Preliminary results show that multi-parametric MRI is promising in the characterization of LGMD subtypes on the thigh. Considered MRI techniques show different sensibilities to damages induced by muscular dystrophies and can be considered complimentary.

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