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Abstract #2241

Multi-parametric assessment of thigh muscles in patients with limb girdle muscular dystrophies (LGMD): preliminary results.

Alberto De Luca1,2, Maria Grazia D'Angelo3, Denis Peruzzo2, Fabio Triulzi4, Alessandra Bertoldo1, and Filippo Arrigoni2

1Department of Information Engineering, University of Padova, Padova, Italy, 2Neuroimaging Lab, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, 3Functional Rehabilitation Unit, Neuromuscular Disorders, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, 4Department of Neuroradiology, Scientific Institute IRCCS Ca Granda Foundation - Ospedale Maggiore Policlinico, Milan, Italy

Limb girdle muscular dystrophies (LGMD) are a heterogeneous family of disorders characterized by the substitution of muscles with fat and fibrotic tissue. In this work we show the initial results of our acquisition protocol, that included DW-MRI, T2 mapping and DIXON imaging, on two subtypes of LGMD (type 2A and 2B). Statistical tests and Pearson’s correlation were performed on parametric maps at single muscle level. Preliminary results show that multi-parametric MRI is promising in the characterization of LGMD subtypes on the thigh. Considered MRI techniques show different sensibilities to damages induced by muscular dystrophies and can be considered complimentary.

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