Abstract #2242

Multiparametric voxel-based analysis of standardized uptake values and apparent diffusion coefficients in soft-tissue tumors with a positron emission tomography-magnetic resonance system: Application for evaluation of treatment effect

Koji Sagiyama¹, Yuji Watanabe², Ryotaro Kamei¹, Sungtak Hong³, Satoshi Kawanami², Yoshihiro Matsumoto⁴, and Hiroshi Honda¹

¹Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Healthcare, Philips Electronics Japan, Fukuoka, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

A combination of single measurements would be necessary to improve the efficacy of evaluating the treatment effect in heterogeneous soft-tissue tumors. This study aimed to investigate the feasibility of direct voxel-by-voxel comparison of SUVs and ADCs with the PET/MR system in the evaluation of the treatment effect in soft-tissue tumors. The ADCs and SUVs were recorded on a voxel-by-voxel basis for all slices. The scatter plots clearly demonstrated significant difference between pre- and post-treatment. Multiparametric voxel-based analysis of SUVs and ADCs could be a promising tool for evaluating the treatment effect in soft-tissue tumors.

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