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Abstract #2242

Multiparametric voxel-based analysis of standardized uptake values and apparent diffusion coefficients in soft-tissue tumors with a positron emission tomography-magnetic resonance system: Application for evaluation of treatment effect

Koji Sagiyama1, Yuji Watanabe2, Ryotaro Kamei1, Sungtak Hong3, Satoshi Kawanami2, Yoshihiro Matsumoto4, and Hiroshi Honda1

1Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Healthcare, Philips Electronics Japan, Fukuoka, Japan, 4Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

A combination of single measurements would be necessary to improve the efficacy of evaluating the treatment effect in heterogeneous soft-tissue tumors. This study aimed to investigate the feasibility of direct voxel-by-voxel comparison of SUVs and ADCs with the PET/MR system in the evaluation of the treatment effect in soft-tissue tumors. The ADCs and SUVs were recorded on a voxel-by-voxel basis for all slices. The scatter plots clearly demonstrated significant difference between pre- and post-treatment. Multiparametric voxel-based analysis of SUVs and ADCs could be a promising tool for evaluating the treatment effect in soft-tissue tumors.

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