Morphological, Compositional, and Fiber Architectural Changes in from Unilateral Limb Suspension Induced Acute Atrophy Model in the Medial Gastrocnemius Muscle.
Shantanu Sinha1, Vadim Malis2, Robert Csapo1, Jiang Du1, and Usha Sinha3
1Radiology, University of California at San Diego, San Diego, CA, United States, 2Physics, University of California at San Diego, San Diego, CA, United States, 3Physics, San Diego State University, San Diego, CA, United States
Acute muscle atrophy is characterized by a loss
of muscle mass and muscle force. Changes
are likely to occur in muscle composition, microenvironment, and fiber
architecture which could impact muscle function. This study focuses on the
changes in these parameters using MR based fat and connective tissue
quantification and DTI in a model of acute atrophy induced by Unilateral limb
suspension (ULLS). The % changes in fat
and connective tissue were minimal while significant decreases were found in fiber
diameter (decrease) and in the pennation angle.
These changes could be primarily responsible for muscle force loss in
acute atrophy.
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