Abstract #2247

Morphological, Compositional, and Fiber Architectural Changes in from Unilateral Limb Suspension Induced Acute Atrophy Model in the Medial Gastrocnemius Muscle.

Shantanu Sinha¹, Vadim Malis², Robert Csapo¹, Jiang Du¹, and Usha Sinha³

¹Radiology, University of California at San Diego, San Diego, CA, United States, ²Physics, University of California at San Diego, San Diego, CA, United States, ³Physics, San Diego State University, San Diego, CA, United States

Acute muscle atrophy is characterized by a loss of muscle mass and muscle force. Changes are likely to occur in muscle composition, microenvironment, and fiber architecture which could impact muscle function. This study focuses on the changes in these parameters using MR based fat and connective tissue quantification and DTI in a model of acute atrophy induced by Unilateral limb suspension (ULLS). The % changes in fat and connective tissue were minimal while significant decreases were found in fiber diameter (decrease) and in the pennation angle. These changes could be primarily responsible for muscle force loss in acute atrophy.

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