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Abstract #2253

Toward a 7T MRI protocol for the evaluation of early osteoarthritis in knee cartilage

Daniel J. Park1, Neal K. Bangerter2,3, Antony J. R. Palmer1, Haonan Wang2, Bragi Sveinsson4, Brian Hargreaves4, and Siôn Glyn-Jones1

1Nuffield Department of Orthopaedics, Rheumotology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, 3Department of Radiology, Univerisity of Utah, Salt Lake City, UT, United States, 4Radiology, Stanford University, Stanford, CA, United States

Osteoarthritis, a disease that is a burden to society and individuals, has 3 major stages of progression in cartilage: (1) glycosaminoglycan loss; (2) collagen matrix degeneration; and (3) fissures and volume and thickness loss. A protocol is proposed to measure the progression of each of these stages of OA at 7 Tesla in about 30 minutes: (1) T1ρ to measure glycosaminoglycan changes; (2) modified DESS measurements of T2 and ADC to measure collagen matrix integrity; and (3) high resolution phase cycled bSSFP images to measure changes in morphology.

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