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Abstract #2254

3D Longitudinal MRI studies on novel tissue-engineered bone constructs in living rats : Volume & Perfusion assessments

Neha KOONJOO1,2, Clément Tournier3, Aurélien Trotier1,2, Didier Wecker4, William Lefrançois1,2, Didier Letourneur5, Joëlle Amédée Vilamitjana3, Sylvain Miraux1,2, and Emeline J Ribot1,2

1CNRS-UMR 5536, Centre de Résonance Magnetique des Systèmes Biologiques, Bordeaux, France, Metropolitan, 2University of Bordeaux, Bordeaux, France, Metropolitan, 3U1026, Bioingénierie Tissulaire (BioTis), Bordeaux, France, Metropolitan, 4Bruker Biospin MRI GMBH, Ettlingen, Germany, 5INSERM U 1148, Cardiovascular Bio-engineering Laboratory, Paris, France, Metropolitan

In tissue engineering, correct bone regeneration in large bone defects is a major issue. MRI has revealed its high potential to assess continuous tracking of three differently conditioned bone constructs implanted in the rats’ femoral condyles. These constructs aimed at evaluating cumulative effects of hydroxyapatite and/or fucoidan in osteogenesis and vascularization. A water-selective bSSFP sequence with fat suppression and banding artifacts correction was implemented for volumetric measurements. 3D Dynamic-contrast enhanced MRI was applied and pixel-wise analysis resulted in fairly good constructs perfusion evaluation. 3D images spotted distinct volume changes and promising area under curve evolution.

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