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Abstract #2255

Quantifying bone marrow inflammatory edema in psoriatic arthritis using pixel-based morphometry

Ioanna Chronaiou1,2, Ruth Stoklund Thomsen 3, Else-Marie Huuse-Røneid 2,3, and Beathe Sitter1

1Department of Radiography, Sør-Trøndelag University College, Trondheim, Norway, 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 3St Olav's University Hospital, Trondheim, Norway

Psoriatic arthritis (PsA) is a highly heterogeneous inflammatory disease that manifests with inflammation in sacroiliac (SI) joints and spine among other symptoms. PsA patients (N=12) underwent magnetic resonance (MR) imaging examinations to assess the extent of SI joint inflammation. A pixel-based morphometric method for accurate quantification of bone marrow inflammatory edema was compared to SPARCC assessment in MR images of psoriatic arthritis patients with low or very low inflammatory activity. A significant correlation was found, suggesting pixel-based morphometry as a reliable and sensitive quantitative method for measuring inflammation in bone marrow.

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