Abstract #2258

Cortical bone quality as a biomarker for diabetes risk in post-menopausal Chinese-Singaporean women: a preliminary study

Francesca A. A. Leek¹, Anna Therese Sjoholm¹, Christiani Jeyakumar Henry², Xiaodi Su³, Marlena C. Kruger⁴, and John J. Totman¹

¹A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore, ²A*STAR Clinical Nutrition Research Centre, Singapore, Singapore, ³A*STAR Institute of Materials Research and Engineering, Singapore, Singapore, ⁴School of Food and Nutrition, College of Health, Massey University, Palmerston North, New Zealand

The feasibility of utilising proximal femur cortical bone quality as a biomarker for diabetes risk in post-menopausal Chinese-Singaporean women was investigated. Non-dominant proximal femurs were imaged with quantitative CT (QCT) and MR for the assessment of volumetric bone mineral density (vBMD) and cortical bone porosity. A significant (p<0.01; n=8) positive correlation between MRI vBMD and QCT vBMD for the region of maximum cortical thickness was shown. Whether MRI vBMD is associated with fracture risk and if it is sensitive to changes due to dietary or drug intervention needs to be investigated to fully assess the clinical potential of this method.

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