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Abstract #2259

Assessment of trabecular bone quality of the proximal femur in vivo: A Preliminary Study

Maria Kalimeri1, Christiani Jeyakumar Henry2, Xiao Di Su3, Marlena C. Kruger4, and John J. Totman1

1A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore, 2Clinical Nutrition Research Centre, Singapore, Singapore, 3Institute of Materials Research and Engineering, Singapore, Singapore, 4School of Food and Nutrition, College of Health, Massey University, Palmerston North, New Zealand

Osteoporosis is a skeletal disorder that affects predominantly postmenopausal women. The screening method for osteoporosis is Dual X-ray Absorptiometry (DXA), which has several limitations, including the inability to differentiate between trabecular and cortical bone. 3D imaging modalities can give information about each bone component, which contribute to bone strength in different ways. MRI is an attractive alternative due to lack of ionising radiation. In this abstract, we present a method for bone density assessment of trabecular bone in the proximal femur using MRI. Strong correlations with both DXA and Quantitative Computed Tomography (QCT) measurements of similar regions were observed.

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