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Abstract #2265

Observation of in vivo lactate metabolism in skeletal muscle using hyperpolarized 13C MRS

JAE MO PARK1, Sonal Josan1, Dirk Mayer2, Ralph E Hurd3, Youngran Chung4, David Bendahan5, Daniel M Spielman1, and Thomas Jue4

1Radiology, Stanford University, Stanford, CA, United States, 2Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, 3Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States, 4Biochemistry and Molecular Medicine, University of California - Davis, Davis, CA, United States, 5Centre de Resonance Magnetique Biologique et Medicale, Aix-Marseille University, Marseille, France

The present study reports the use of hyperpolarized [1-13C]lactate and [2-13C]pyruvate to measure the rapid pyruvate and lactate kinetics in rat skeletal muscle. The results provide support for a critical underpinning of both the glycogen shunt model and the intracellular lactate shuttle hypothesis, and cautions against an overly simplistic view of glycolytic end products as merely hypoxia biomarkers.

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