Abstract #2265

Observation of in vivo lactate metabolism in skeletal muscle using hyperpolarized 13C MRS

JAE MO PARK¹, Sonal Josan¹, Dirk Mayer², Ralph E Hurd³, Youngran Chung⁴, David Bendahan⁵, Daniel M Spielman¹, and Thomas Jue⁴

¹Radiology, Stanford University, Stanford, CA, United States, ²Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, ³Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States, ⁴Biochemistry and Molecular Medicine, University of California - Davis, Davis, CA, United States, ⁵Centre de Resonance Magnetique Biologique et Medicale, Aix-Marseille University, Marseille, France

The present study reports the use of hyperpolarized [1-¹³C]lactate and [2-¹³C]pyruvate to measure the rapid pyruvate and lactate kinetics in rat skeletal muscle. The results provide support for a critical underpinning of both the glycogen shunt model and the intracellular lactate shuttle hypothesis, and cautions against an overly simplistic view of glycolytic end products as merely hypoxia biomarkers.

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