Abstract #2266

Quantitative magnetization transfer MRI of in-situ and ex-situ meniscus

Mikaël Simard¹, Emily J. McWalter², Garry E. Gold², and Ives R. Levesque^1,3

¹Medical Physics, McGill University, Montreal, QC, Canada, ²Radiology, Stanford University, Stanford, CA, United States, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada

Quantitative magnetization transfer (QMT) probes macromolecular content in tissue and may be a useful tool in the early detection of meniscal degeneration. QMT mapping of the meniscus was performed in 3 cadaver knee specimens in situ, and repeated ex situ following dissection and immersion in perflubron. After extraction, a decrease in the restricted pool fraction f was noted, while T1obs and T1f increased. A trend towards lower values of the exchange rate kf was noted after excision. T2 and T2r were relatively constant. The variation in QMT parameters may be caused by the diffusion of perflubron into the ex situ samples.

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