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Abstract #2267

Ultrashort echo time magnetization transfer (UTE-MT) imaging and modeling – magic angle independent biomarkers of tissue properties

Yajun Ma1, Hongda Shao1, Michael Carl2, Eric Chang1, and Jiang Du1

1Department of Radiology, UCSD, San Diego, CA, United States, 2Global MR Application & Workflow, General Electric, San Diego, CA, United States

Magnetic resonance imaging biomarkers such as T2 and T1rho have been widely used in the evaluation of osteoarthritis (OA). The principal confounding factor for T2 and T1rho measures is the magic angle effect, which may result in a several fold increase in T2 and T1rho values when the fibers are oriented near 55° (the magic angle) relative to the B0 field. This often far exceeds the changes produced by OA, and may make definitive interpretation of elevated T1rho and T2 values difficult or impossible. Magic angle independent MR biomarkers are highly desirable for more accurate assessment of OA. In this study we report the use of two-dimensional ultrashort echo time magnetization transfer (UTE-MT) imaging and modeling for magic angle independent assessment of the tissue properties.

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