Abstract #2275

Study of Hemodynamics in Human Calf Muscle during Low-Intensity Exercise Using Single-Subject Independent Component Analysis

Zhijun Li¹, Prasanna Karunanayaka¹, Matthew Muller², Christopher Sica¹, Jian-Li Wang¹, Lawrence Sinoway², and Qing X. Yang^1,3

¹Center for NMR Research, Department of Radiology, College of Medicine, The Pennsylvania State University, Hershey, PA, United States, ²Heart and Vascular Institute, College of Medicine, The Pennsylvania State University, Hershey, PA, United States, ³Department of Neurosurgery, College of Medicine, The Pennsylvania State University, Hershey, PA, United States

Unlike in human brain imaging, normalization to a common template during exercising is a difficult proposition in muscle-imaging studies. Still, motion artifact has been an issue for dynamic analysis of exercise paradigm. We used individual Independent Component Analysis (ICA) to identify the “motion component” during exercise (rhythmic plantar-flexion) and anatomical and temporal features of BOLD signal. We simultaneously identified the lower leg muscle groups and their common hemodynamic behaviors under a low-level exercise paradigm and revealed an intriguing hemodynamic respond characteristic with a prominent transient increase and followed by a negative BOLD signal sustained to the end of exercise.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.